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Mitglieder

Das GRK 2158 setzt sich aus den Projektleiterinnen und Projektleitern und Doktorandinnen und Doktoranden aus 14 Teams der Bereiche Pharmazie, Chemie und Medizin der Heinrich-Heine-Universität Düsseldorf (HHU) sowie assoziierter Arbeitsgruppen andere Institutionen zusammen.

Seit 2016 fördert die DFG 12 Promotionsvorhaben für jeweils 3 Jahre in 12 Teams der Pharmazie, Chemie und Medizin. Assoziierte Wissenschaftler und Mercator Fellows sowie assoziierte Doktoranden tragen zum Erfolg der wissenschaftlichen Ziele des GRK bei.

Foto von Sanil Bhatia
Dr. Sanil Bhatia

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Foto von Gerhard Fritz
Prof. Dr. Gerhard Fritz

Institute of Toxicology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Foto von Holger Gohlke
Prof. Dr. Holger Gohlke

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Foto von Rainer Kalscheuer
Prof. Dr. Rainer Kalscheuer

Institute of Pharmaceutical Biology and Biotechnology

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Foto von Matthias Kassack
Prof. Dr. Matthias Kassack

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Foto von Thomas Kurz
Prof. Dr. Thomas Kurz

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Foto von Thomas J. J. Müller
Prof. Dr. Thomas J. J. Müller

Institute of Organic Chemistry and Macromoleculare Chemistry

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Foto von Klaus Pfeffer
Prof. Dr. Klaus Pfeffer

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Foto von Jörg Pietruszka
Prof. Dr. Jörg Pietruszka

Institute of Bioorganic Chemistry

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Foto von Stefanie Scheu
Prof. Dr. Stefanie Scheu

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Foto von Sander Smits
Dr. Sander Smits

Institute of Biochemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Foto von Holger Stark
Prof. Dr. Holger Stark

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Foto von Björn Stork
Prof. Dr. Björn Stork

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Foto von Sebastian Wesselborg
Prof. Dr. Sebastian Wesselborg

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Foto von Emmanuel Tola Adeniyi
Emmanuel Tola Adeniyi

Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products

Project Area 3

Project Description

Foto von Jana Aengenvoort, née van Stuijvenberg
Jana Aengenvoort, née van Stuijvenberg

Project Title: Targeting mechanisms of DNA damage response (DDR) to overcome anticancer drug resistance of tumor cells

Project Area 3

Project Description

Foto von Lena Berning
Lena Berning

Project Title: Characterization of autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Project Area 1

Project Description

Foto von Pablo Cea Medina
Pablo Cea Medina

Project Title: Structure based drug design against Nisin resistance systems

Project Area 4

Project Description

Foto von Mariam Dubiel
Mariam Dubiel

Project Title: Novel modulators in sphingolipid signaling

Project area 4

Project Description

Foto von Fabian Fischer
Fabian Fischer

Project Title: Development of chemosensitizing HDAC-Inhibitors, HDAC-PROTACs and HDAC-Inhibitors with fluorescent Cap-groups

Project area 2

Project description

Foto von Julia Gottstein
Julia Gottstein

Project Title: Lantibiotic resistance in human pathogens

Project area 4

Project Description

Foto von Julian Greb
Julian Greb

Project Title: Towards the synthesis of xanthone based natural products and their analogs

Project area 1

Project Description

Foto von Moritz Klischan
Moritz Klischan

Project Title: Biaryl-based natural products as structural motif for pharmaceutically relevant compounds

Project area 1

Project Description

Foto von Marco Kruppa
Marco Kruppa

Project Title: Diversity-oriented synthesis of symmetrically and unsymmetrically substituted Alocasin A-derivatives against therapy resistant bacteria

Project area 3

Project Description

Foto von Flaminia Mazzone
Flaminia Mazzone

Project Title: Identification and characterization of new natural products with anti-microbial activity against Apicomplexa and multiresistant gram-negative rods (4MRGN)

Project area 3

Project Description

Foto von Nicola Porta
Nicola Porta

Project Title: Overcoming Lantibiotics resistance in bacterial pathogens: Nisin as a model system

Project area 4

Project Description

Foto von Julian Schliehe-Diecks
Julian Schliehe-Diecks

Project Title: Characterization of synergy and resistance traits of HSP90 and HDAC inhibitors in leukemic cell lines

Project area 2

Project Description

Foto von Laura Schmitt
Laura Schmitt

Project Title: Elimination of chemotherapy-resistant tumors by natural product-induced cell death

Project area 1

Project Description

Foto von Marlena Sekeres
Marlena Sekeres

Project Title: Modulation of the DNA damage response (DDR) by natural compounds (NC) to widen the therapeutic window of anticancer drugs

Project area 2

Project Description

Foto von Xiaoli Yang
Xiaoli Yang

Project Title: Identification immune activating characteristics of HDAC inhibitors and natural products as novel treatment options for chemoresistant tumors and bacterial pathogens

Project area 2

Project Description

Foto von David Bickel
David Bickel

Project Title: Lead structure generation for HSP90 dimerization inhibitors and classification of protein-protein interfaces

Project description

Foto von Annabelle Friedrich
Annabelle Friedrich

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Foto von Ilka Hinxlage
Ilka Hinxlage

Project Title: Identification of novel apoptotic signaling pathways for the elimination of therapy-resistant tumors

Project description

Larissa Hinz

Project Title: Modular synthesis of Indolophenazine-Derivatives as active agents against Toxoplasma gondii

Project description

Stefan Höfmann

Project Title:

Project description

Foto von Niklas Janzing
Niklas Janzing

Project Title: Isolation and functional analysis of DNA gyrase inhibitors from Streptomyces species

Project description

Foto von Talea Knak
Talea Knak

Project Title: Structural Optimization of Chlorflavonin – a natural compound with antimycobacterial activity

Project description

Foto von Laura Mayer
Laura Mayer

Project Title: Diversity-oriented synthesis of diaryl substituted heterocycles via sequential palladium catalysis

Project description

Foto von Korana Mudrovcic
Korana Mudrovcic

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Foto von Christian Schrenk
Christian Schrenk

Project Title: Biological Characterization of (class IIa) HDAC-Inhibitors with chemosensitising properties as anticancer agents

Project description

Foto von Tino Seidemann
Tino Seidemann

Project Title: Bioactivity of natural products against Mycobacterium tuberculosis

Project description

Foto von Lars Seiffert
Lars Seiffert

Project Title: Synthesis of small-molecule inhibitors of nisin resistance protein

Project description

Foto von Titus Watrin
Titus Watrin

Project title: Ex vivo high throughput drug screening to find novel biomarkers in childhood acute leukemia

Project area 3

Project description

Koordinatorin

Dr. Martina Holz
Gebäude: 26.21
Etage/Raum: U1.28
+49 211 81-15592

Dr. Yodita Asfaha
Dr. Philip Böhler
Dr. Hjördis Brückmann
Dr. Jana Deitersen
Dr. Daniel Drießen
Dr. Annika Frank
Dr. Yvonne Gröner
Dr. Mariam Moussa
Dr. Marc Pflieger
Prof. Dr. Dr. h.c. Peter Proksch
Dr. Lisa Richter
Dr. David Schlütermann
Dr. Julia Schumacher (née Zaschke-Kriesche)
Dr. Shabnam Shaneh Sazzadeh
Dr. Gereon Sommer
Dr. Julia Sperlich
Fabian Stuhldreier
Dr. Nam Michael Tran-Cong
Dr. Chenyin Wang
Dr. Anja Weber (née Ullrich)
Verantwortlichkeit: