Mitglieder
Das GRK 2158 setzt sich aus den Projektleiterinnen und Projektleitern und Doktorandinnen und Doktoranden aus 14 Teams der Bereiche Pharmazie, Chemie und Medizin der Heinrich-Heine-Universität Düsseldorf (HHU) sowie assoziierter Arbeitsgruppen andere Institutionen zusammen.
Seit 2016 fördert die DFG 12 Promotionsvorhaben für jeweils 3 Jahre in 12 Teams der Pharmazie, Chemie und Medizin. Assoziierte Wissenschaftler und Mercator Fellows sowie assoziierte Doktoranden tragen zum Erfolg der wissenschaftlichen Ziele des GRK bei.
Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology
Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors
Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors
Institute of Pharmaceutical and Medicinal Chemistry
Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.
Institute of Pharmaceutical Biology and Biotechnology
Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)
Institute of Pharmaceutical and Medicinal Chemistry
Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors
Institute of Pharmaceutical and Medicinal Chemistry
Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors
Institute of Organic Chemistry and Macromoleculare Chemistry
Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)
Institute of Medical Microbiology and Hospital Hygiene
Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)
Institute of Bioorganic Chemistry
Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells
Institute of Medical Microbiology and Hospital Hygiene
Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors
Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.
Institute of Pharmaceutical and Medicinal Chemistry
Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.
Institute of Molecular Medicine I
Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells
Institute of Molecular Medicine I
Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells
Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products
Project Area 3
Project Title: Development of selective histone deacetylase inhibitors (HDACi) and HDAC-based targeted protein degraders (TPD)
Project Area 2
Project Title: Characterization of autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells
Project Area 1
Project Title: Autophagy-modulating natural products – synthesis of tripyrrol-based derivatives
Project Area 1
Project Title: Identification and characterization of new agents with antimicrobial activity against apicomplexa and multidrug-resistant Gram-negative rod bacteria (4MRGN)
Project area 3
Project Title: Structure based drug design against Nisin resistance systems
Project Area 4
Project Title: Characterization of autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells
Project area 1
Project Title: Development of chemosensitizing HDAC-Inhibitors, HDAC-PROTACs and HDAC-Inhibitors with fluorescent Cap-groups
Project area 2
Project Title: Towards the synthesis of xanthone based natural products and their analogs
Project area 1
Project Title: Multitargeting Approaches in Antimicrobial/Anticancer Drug Developments
Project Area 4
Project Title: Biaryl-based natural products as structural motif for pharmaceutically relevant compounds
Project area 1
Project Title: Elimination of anticancer drug resistant tumors by natural product drug induced cell death
Project area 1
Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products
Project area 3
Project Title: Diversity-oriented synthesis of symmetrically and unsymmetrically substituted Alocasin A-derivatives against therapy resistant bacteria
Project area 3
Project Title: Anticancer efficacy of combinations of histone deacetylase inhibitors and conventional and targeted anticancer therapeutics
Project area 2
Project Title: The nisin resistance operon from S. agalactiae: A modelsystem to inhibit lantibiotic resistance in human pathogens
Project Area 4
Project Title: Identification and characterization of new natural products with anti-microbial activity against Apicomplexa and multiresistant gram-negative rods (4MRGN)
Project area 3
Project Title: Diversity-oriented synthesis of biheteroaryls as apoptosis inducers and biindole derivatives with variable (hetero)cyclic bridges against therapy resistant bacteria
Project Area 3
Project Title: Elucidation of the mechanisms of action of immune‐activating HDAC inhibitors and natural products for the development of new therapeutic approaches against chemoresistant tumor cells and bacterial pathogens
Project area 2
Project Title: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens and molecular modeling to optimize antitumor and antimicrobial agents
Project Area 4
Project Title: Characterization of synergy and resistance traits of HSP90 and HDAC inhibitors in leukemic cell lines
Project area 2
Project Title: Elimination of chemotherapy-resistant tumors by natural product-induced cell death
Project area 1
Project Title: Modulation of the DNA damage response (DDR) by natural compounds (NC) to widen the therapeutic window of anticancer drugs
Project area 2
Project Title: Development of novel HDAC inhibitors to overcome resistance in therapy refractory childhood acute leukemia
Project Area 2
Project Title: Identification immune activating characteristics of HDAC inhibitors and natural products as novel treatment options for chemoresistant tumors and bacterial pathogens
Project area 2
Project Title: Development of subtype class I selective histone deacetylase inhibitors and degraders to revert and prevent therapy resistance in cancer.
Project description
Project Title: Immunocompetent 3D pancreatic adenocarcinoma (PDAC) BioChip model for preclinical drug testing
Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy
Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products
Project Title: Identification of novel apoptotic signaling pathways for the elimination of therapy-resistant tumors
Project Title: Modular synthesis of Indolophenazine-Derivatives as active agents against Toxoplasma gondii
Project Title: Modulating protein-protein interactions to inhibit HDAC function selectively
Project Title: Preclinical development of IspC and IspH inhibitors of mevalonate-independent isoprenoid biosynthesis, including development of siderophore inhibitor conjugates and protein degraders.
Project Title: Isolation and functional analysis of DNA gyrase inhibitors from Streptomyces species
Project Title: Inhibiting the CoREST complex with dual HDAC1,2 - LSD and protein-protein interaction inhibitors
Project Title: Structural Optimization of Chlorflavonin – a natural compound with antimycobacterial activity
Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy
Project Title: Biological Characterization of (class IIa) HDAC-Inhibitors with chemosensitising properties as anticancer agents
Project Title: Synthesis of small-molecule inhibitors of nisin resistance protein
Project title: Anticancer efficacy and adverse effects of natural compounds/histone deacetylase inhibitors and conventional anticancer therapeutics
Project area 2 (Working Group of Matthias Kassack)
Project title: Anticancer efficacy and adverse effects of natural compounds/histone deacetylase inhibitors and conventional anticancer therapeutics
Project area 2 (Working Group of Gerhard Fritz)
Koordinatorin
Etage/Raum: U1.28