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Members

The GRK 2158 is composed of the Principal Inventors and PhD students from 14 teams from the fields of pharmacy, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU).

Since 2016, the DFG has been funding 12 doctoral projects for 3 years each in 12 teams in pharmacy, chemistry and medicine. Associated scientists and Mercator Fellows as well as associated doctoral students contribute to the success of the scientific goals of the GRK. 

Photo of Sanil Bhatia
Dr. Sanil Bhatia

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Gerhard Fritz
Prof. Dr. Gerhard Fritz

Institute of Toxicology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Holger Gohlke
Prof. Dr. Holger Gohlke

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Rainer Kalscheuer
Prof. Dr. Rainer Kalscheuer

Institute of Pharmaceutical Biology and Biotechnology

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Matthias Kassack
Prof. Dr. Matthias Kassack

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Thomas Kurz
Prof. Dr. Thomas Kurz

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Thomas J. J. Müller
Prof. Dr. Thomas J. J. Müller

Institute of Organic Chemistry and Macromoleculare Chemistry

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Klaus Pfeffer
Prof. Dr. Klaus Pfeffer

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Jörg Pietruszka
Prof. Dr. Jörg Pietruszka

Institute of Bioorganic Chemistry

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Stefanie Scheu
Prof. Dr. Stefanie Scheu

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Sander Smits
Prof. PD Dr. Sander Smits

Institute of Biochemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Holger Stark
Prof. Dr. Holger Stark

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Björn Stork
Prof. Dr. Björn Stork

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Sebastian Wesselborg
Prof. Dr. Sebastian Wesselborg

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Emmanuel Tola Adeniyi
Emmanuel Tola Adeniyi

Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products

Project Area 3

Project Description

Photo of Christian Anzenhofer
Christian Anzenhofer

Project Title: Development of selective histone deacetylase inhibitors (HDACi) and HDAC-based targeted protein degraders (TPD)

Project Area 2

Project Description

Photo of Matthias Bleser
Matthias Bleser

Project Title: Autophagy-modulating natural products – synthesis of tripyrrol-based derivatives

Project Area 1

Project Description

Photo of Imke Bradtmöller
Imke Bradtmöller

Project Title: Identification and characterization of new agents with antimicrobial activity against apicomplexa and multidrug-resistant Gram-negative rod bacteria (4MRGN)

Project area 3

Project Description

Photo of Pablo Cea Medina
Pablo Cea Medina

Project Title: Structure based drug design against Nisin resistance systems

Project Area 4

Project Description

Photo of Céline David
Céline David

Project Title: Characterization of autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Project area 1

Project Description

Photo of Mariam Dubiel
Mariam Dubiel

Project Title: Novel modulators in sphingolipid signaling

Project area 4

Project Description

Photo of Jitheesh Joy
Jitheesh Joy

Project Title: Multitargeting Approaches in Antimicrobial/Anticancer Drug Developments

Project Area 4

Project Description

Photo of Moritz Klischan
Moritz Klischan

Project Title: Biaryl-based natural products as structural motif for pharmaceutically relevant compounds

Project area 1

Project Description

Photo of Karina Krings
Karina Krings

Project Title: Elimination of anticancer drug resistant tumors by natural product drug induced cell death

Project area 1

Project Description

Photo of Violetta Krisilia
Violetta Krisilia

Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products

Project area 3

Project Description

Photo of Jingyu Li
Jingyu Li

Project Title: Anticancer efficacy of combinations of histone deacetylase inhibitors and conventional and targeted anticancer therapeutics

Project area 2

Project Description

Photo of Christian Mammen
Christian Mammen

Project Title: The nisin resistance operon from S. agalactiae: A modelsystem to inhibit lantibiotic resistance in human pathogens

Project Area 4

Project Description

Photo of Alae-Eddine Moubsit
Alae-Eddine Moubsit

Project Title: Diversity-oriented synthesis of biheteroaryls as apoptosis inducers and biindole derivatives with variable (hetero)cyclic bridges against therapy resistant bacteria

Project Area 3

Project Description

Photo of Adarsh Nair
Adarsh Nair

Project Title: Elucidation of the mechanisms of action of immune‐activating HDAC inhibitors and natural products for the development of new therapeutic approaches against chemoresistant tumor cells and bacterial pathogens  

Project area 2

Project Description

Photo of Gürbüz Önder
Gürbüz Önder

Project Title: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens and molecular modeling to optimize antitumor and antimicrobial agents

Project Area 4

project description

Photo of Julian Schliehe-Diecks
Julian Schliehe-Diecks

Project Title: Characterization of synergy and resistance traits of HSP90 and HDAC inhibitors in leukemic cell lines

Project area 2

Project Description

Photo of Marlena Sekeres
Marlena Sekeres

Project Title: Modulation of the DNA damage response (DDR) by natural compounds (NC) to widen the therapeutic window of anticancer drugs

Project area 2

Project Description

Photo of Jia-Wey Tu
Jia-Wey Tu

Project Title: Development of novel HDAC inhibitors to overcome resistance in therapy refractory childhood acute leukemia

Project Area 2

Project Description

Photo of Fabian Fischer
Fabian Fischer

Project Title: Development of chemosensitizing HDAC-Inhibitors, HDAC-PROTACs and HDAC-Inhibitors with fluorescent Cap-groups

Project area 2

Project description

Lukas Biermann

Project Title: Development of subtype class I selective histone deacetylase inhibitors and degraders to revert and prevent therapy resistance in cancer.

Project description

 

Photo of Alina Deipenbrock
Alina Deipenbrock

Project Title: Immunocompetent 3D pancreatic adenocarcinoma (PDAC) BioChip model for preclinical drug testing

Project description

Photo of Annabelle Friedrich
Annabelle Friedrich

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Photo of Di He
Di He

Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products

Project description

Photo of Larissa Hinz
Larissa Hinz

Project Title: Modular synthesis of Indolophenazine-Derivatives as active agents against Toxoplasma gondii

Project description

Photo of Yu-Lin Ho
Yu-Lin Ho

Project Title: Modulating protein-protein interactions to inhibit HDAC function selectively

Project description

Photo of Stefan Höfmann
Stefan Höfmann

Project Title: Preclinical development of IspC and IspH inhibitors of mevalonate-independent isoprenoid biosynthesis, including development of siderophore inhibitor conjugates and protein degraders.

Project description

Photo of Niklas Janzing
Niklas Janzing

Project Title: Isolation and functional analysis of DNA gyrase inhibitors from Streptomyces species

Project description

Photo of Franziska Kinnen
Franziska Kinnen

Project Title: Inhibiting the CoREST complex with dual HDAC1,2 - LSD and protein-protein interaction inhibitors

Project description

Photo of Talea Knak
Talea Knak

Project Title: Structural Optimization of Chlorflavonin – a natural compound with antimycobacterial activity

Project description

Photo of Ilka Lechtenberg (née Hinxlage)
Ilka Lechtenberg (née Hinxlage)

Project Title: Identification of novel apoptotic signaling pathways for the elimination of therapy-resistant tumors

Project description

Photo of Korana Mudrovcic
Korana Mudrovcic

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Photo of Christian Schrenk
Christian Schrenk

Project Title: Biological Characterization of (class IIa) HDAC-Inhibitors with chemosensitising properties as anticancer agents

Project description

Photo of Lars Seiffert
Lars Seiffert

Project Title: Synthesis of small-molecule inhibitors of nisin resistance protein

Project description

Photo of Kira Tantsur
Kira Tantsur

Project Title: Structure function relationship of the novel lantibiotic maddinglicin and its biosynthetic machinery

Project description

Photo of Tobias Wassenberg
Tobias Wassenberg

Project Title: Diversity-oriented synthesis of novel Meriolins as apoptosis inducers for potential cancer treatment

Project description

Project Area 3

 

Photo of Svenja Oschem
Svenja Oschem

Project title: Characterization of autophagy-modulating HSP90 inhibitors

Project area 1 (Working Group of Björn Stork)

Photo of Lena Pollmann
Lena Pollmann

Project title: Klonierung des humanen CD40-L Gens für die Erzeugung eines rekombinanten
Mycobacterium bovis BCG Stamms für die therapeutische Tumorvakzinierung

Project area 3 (Working Group of Rainer Kalscheuer)

Coordinator

Dr. Martina Holz
Building: 26.21
Floor/Room: U1.28
+49 211 81-15592



Prof. Dr. Dr. h.c. Peter Proksch
Dr. Jana Aengenvoort, née van Stuijvenberg
Dr. Lena Berning
Dr. Daniel Drießen
Dr. Jana Emontz (née Deitersen)
Dr. Annika Frank
Dr. Julia Gottstein
Julian Greb
Dr. Yvonne Gröner
Dr. Marco Kruppa
Flaminia Mazzone
Nicola Porta
Dr. Lisa Richter
Dr. Laura Schmitt
Dr. Julia Schumacher (née Zaschke-Kriesche)
Dr. Shabnam Shaneh Sazzadeh
Dr. Fabian Stuhldreier
Dr. Nam Michael Tran-Cong
Xiaoli Yang
Dr. Yodita Asfaha
Dr. David Bickel
Dr. Philip Böhler
Dr. Hjördis Brückmann
Dr. Laura Mayer
Dr. Mariam Moussa
Dr. Marc Pflieger
Dr. David Schlütermann
Tino Seidemann
Dr. Gereon Sommer
Dr. Julia Sperlich
Dr. Chenyin Wang
Dr. Anja Weber (née Ullrich)
Dr. Haiqian Yu
Johanna Dartsch
Philipp Ehren
Titus Watrin
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