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Members

The GRK 2158 is composed of the Principal Inventors and PhD students from 14 teams from the fields of pharmacy, chemistry and medicine at Heinrich Heine University Düsseldorf (HHU).

Since 2016, the DFG has been funding 12 doctoral projects for 3 years each in 12 teams in pharmacy, chemistry and medicine. Associated scientists and Mercator Fellows as well as associated doctoral students contribute to the success of the scientific goals of the GRK. 

Photo of Sanil Bhatia
Dr. Sanil Bhatia

Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Gerhard Fritz
Prof. Dr. Gerhard Fritz

Institute of Toxicology

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Holger Gohlke
Prof. Dr. Holger Gohlke

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Rainer Kalscheuer
Prof. Dr. Rainer Kalscheuer

Institute of Pharmaceutical Biology and Biotechnology

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Matthias Kassack
Prof. Dr. Matthias Kassack

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Thomas Kurz
Prof. Dr. Thomas Kurz

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Thomas J. J. Müller
Prof. Dr. Thomas J. J. Müller

Institute of Organic Chemistry and Macromoleculare Chemistry

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Klaus Pfeffer
Prof. Dr. Klaus Pfeffer

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 3: Characterization of the mechanism of action and medicinal chemistry optimization of antimicrobial natural products (chloroflavonin, bisindole and indolo[3,2-a]phenazine)

Photo of Jörg Pietruszka
Prof. Dr. Jörg Pietruszka

Institute of Bioorganic Chemistry

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Stefanie Scheu
Prof. Dr. Stefanie Scheu

Institute of Medical Microbiology and Hospital Hygiene

Project Cluster 2: Natural product/HDAC inhibitor-mediated modulation of immune responses and cytostatic-induced stress responses for resensitization of therapy-resistant tumors

Photo of Sander Smits
Dr. Sander Smits

Institute of Biochemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Holger Stark
Prof. Dr. Holger Stark

Institute of Pharmaceutical and Medicinal Chemistry

Project Cluster 4: Nisin as a model system to overcome lantibiotic resistance in bacterial pathogens.

Photo of Björn Stork
Prof. Dr. Björn Stork

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Sebastian Wesselborg
Prof. Dr. Sebastian Wesselborg

Institute of Molecular Medicine I

Project Cluster 1: Characterization and optimization of apoptosis- and autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Photo of Emmanuel Tola Adeniyi
Emmanuel Tola Adeniyi

Project Title: Characterization of the molecular mechanisms underlying antibacterial activity of natural products

Project Area 3

Project Description

Photo of Jana Aengenvoort, née van Stuijvenberg
Jana Aengenvoort, née van Stuijvenberg

Project Title: Targeting mechanisms of DNA damage response (DDR) to overcome anticancer drug resistance of tumor cells

Project Area 3

Project Description

Photo of Lena Berning
Lena Berning

Project Title: Characterization of autophagy-modulating natural products and derivatives for the elimination of therapy-resistant tumor cells

Project Area 1

Project Description

Photo of Pablo Cea Medina
Pablo Cea Medina

Project Title: Structure based drug design against Nisin resistance systems

Project Area 4

Project Description

Photo of Mariam Dubiel
Mariam Dubiel

Project Title: Novel modulators in sphingolipid signaling

Project area 4

Project Description

Photo of Julia Gottstein
Julia Gottstein

Project Title: Lantibiotic resistance in human pathogens

Project area 4

Project Description

Photo of Julian Greb
Julian Greb

Project Title: Towards the synthesis of xanthone based natural products and their analogs

Project area 1

Project Description

Photo of Moritz Klischan
Moritz Klischan

Project Title: Biaryl-based natural products as structural motif for pharmaceutically relevant compounds

Project area 1

Project Description

Photo of Marco Kruppa
Marco Kruppa

Project Title: Diversity-oriented synthesis of symmetrically and unsymmetrically substituted Alocasin A-derivatives against therapy resistant bacteria

Project area 3

Project Description

Photo of Flaminia Mazzone
Flaminia Mazzone

Project Title: Identification and characterization of new natural products with anti-microbial activity against Apicomplexa and multiresistant gram-negative rods (4MRGN)

Project area 3

Project Description

Photo of Nicola Porta
Nicola Porta

Project Title: Overcoming Lantibiotics resistance in bacterial pathogens: Nisin as a model system

Project area 4

Project Description

Photo of Julian Schliehe-Diecks
Julian Schliehe-Diecks

Project Title: Characterization of synergy and resistance traits of HSP90 and HDAC inhibitors in leukemic cell lines

Project area 2

Project Description

Photo of Laura Schmitt
Laura Schmitt

Project Title: Elimination of chemotherapy-resistant tumors by natural product-induced cell death

Project area 1

Project Description

Photo of Marlena Sekeres
Marlena Sekeres

Project Title: Modulation of the DNA damage response (DDR) by natural compounds (NC) to widen the therapeutic window of anticancer drugs

Project area 2

Project Description

Photo of Xiaoli Yang
Xiaoli Yang

Project Title: Identification immune activating characteristics of HDAC inhibitors and natural products as novel treatment options for chemoresistant tumors and bacterial pathogens

Project area 2

Project Description

Photo of Fabian Fischer
Fabian Fischer

Project Title: Development of chemosensitizing HDAC-Inhibitors, HDAC-PROTACs and HDAC-Inhibitors with fluorescent Cap-groups

Project area 2

Project description

Photo of David Bickel
David Bickel

Project Title: Lead structure generation for HSP90 dimerization inhibitors and classification of protein-protein interfaces

Project description

Photo of Annabelle Friedrich
Annabelle Friedrich

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Photo of Ilka Hinxlage
Ilka Hinxlage

Project Title: Identification of novel apoptotic signaling pathways for the elimination of therapy-resistant tumors

Project description

Larissa Hinz

Project Title: Modular synthesis of Indolophenazine-Derivatives as active agents against Toxoplasma gondii

Project description

Stefan Höfmann

Project Title:

Project description

Photo of Niklas Janzing
Niklas Janzing

Project Title: Isolation and functional analysis of DNA gyrase inhibitors from Streptomyces species

Project description

Photo of Talea Knak
Talea Knak

Project Title: Structural Optimization of Chlorflavonin – a natural compound with antimycobacterial activity

Project description

Photo of Laura Mayer
Laura Mayer

Project Title: Diversity-oriented synthesis of diaryl substituted heterocycles via sequential palladium catalysis

Project description

Photo of Korana Mudrovcic
Korana Mudrovcic

Project Title: Targeting protein-protein interactions within the autophagy-inducing ULK1 complex for cancer therapy

Project description

Photo of Christian Schrenk
Christian Schrenk

Project Title: Biological Characterization of (class IIa) HDAC-Inhibitors with chemosensitising properties as anticancer agents

Project description

Photo of Tino Seidemann
Tino Seidemann

Project Title: Bioactivity of natural products against Mycobacterium tuberculosis

Project description

Photo of Lars Seiffert
Lars Seiffert

Project Title: Synthesis of small-molecule inhibitors of nisin resistance protein

Project description

Coordinator

Dr. Martina Holz
Building: 26.21
Floor/Room: U1.28
+49 211 81-15592

Prof. Dr. Dr. h.c. Peter Proksch
Dr. Jana Deitersen
Dr. Daniel Drießen
Dr. Annika Frank
Dr. Yvonne Gröner
Dr. Lisa Richter
Dr. Julia Schumacher (née Zaschke-Kriesche)
Dr. Shabnam Shaneh Sazzadeh
Fabian Stuhldreier
Dr. Nam Michael Tran-Cong
Dr. Yodita Asfaha
Dr. Philip Böhler
Dr. Hjördis Brückmann
Dr. Mariam Moussa
Dr. Marc Pflieger
Dr. David Schlütermann
Dr. Gereon Sommer
Dr. Julia Sperlich
Dr. Chenyin Wang
Dr. Anja Weber (née Ullrich)
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