Program 2022
The programm will be published here soon.
Monday, 28th November 2022
Time | Speaker | Topic |
13:00 | Holger Gohlke Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University, Düsseldorf | Welcome and Introduction |
13:15 – 14:00 | Roderich Süßmuth Synthetic Biotechnology and Antibiotics, TU Berlin | Peptide natural products as scaffolds for drugs |
| 14:00 - 14:15 | Short Break | |
14:15 – 14:45 | Julia Gottstein Institute of Biochemistry I, Heinrich-Heine-University Düsseldorf | New insights into the resistance mechanism for the BceAB‑type transporter SaNsrFP |
14:45 – 15:15 | Pablo Cea Medina Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University, Düsseldorf | Exploring the structural basis of the inhibiton of Cyclin-dependant kinases by Meriolin derivatives |
15:15 – 16:15 | Poster session & Coffee Break | |
16:15 – 16:45 | Julian Schliehe-Diecks Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology | Characterization of novel class I/IIb HDAC inhibitors and the therapeutic potential of HDAC6 inhibition in BCR-ABL+ leukemia |
16:45 - 17:15 | Fabian Fischer Institute of Pharmaceutical and Medicinal Chemistry, Heinrich-Heine-University, Düsseldorf
| Development of histone-deacetylase (HDAC)-inhibitors and HDAC-PROTACs |
17:15 - 17:25 | Short Break | |
17:25 - 18:10 | George Burslem Perelman School of Medicine, University of Pennsylvania, USA | Chemical Approaches for Modulating Lysine Post-Translational Modifications |
19:00 | Dinner for GRK members & guests | |
Tuesday, 29th November 2022
Time | Speaker | Topic |
9:00 | Isabelle Schalk University of Strasbourg - CNRS, France http://bsc.unistra.fr/en/research-teams/team-schalkmislin/presentation/ | Siderophore-antibiotic conjugates – diverting iron uptake to deliver drugs inside bacteria |
| 9:45 - 10:15 | Marco Kruppa Institute of Organic Chemistry and Macromoleculare Chemistry, Heinrich Heine University | Diversity-oriented synthesis and sidechain functionalization of N-heterocyclic-bridged bisindoles as effective antibiotics against MRSA |
10:15 - 10:45 | Emmanuel Adeniyi Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University | Investigating the molecular mechanisms underlying the antimycobacterial activity of callyaerins |
| 10:45 - 11:15 | Poster session & Coffee Break | |
11:15 – 12:00 | Andreas Strasser The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia | Towards targeting MCL-1 for cancer therapy |
12:00 - 12:30 | Laura Schmitt Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf | Targeting mitochondrial metabolism by the mitotoxin Bromoxib as a therapeutic approach for the treatment of lymphoma |
| 12:30 - 13:00 | Marlena Sekeres Institute of Toxicology, Medical Faculty, Heinrich Heine University Düsseldorf | Modulation of the DNA damage response (DDR) by histone deacetylase inhibitors (HDACi) to widen the therapeutic window of anti-cancer drugs |
13:00 - 14:00 | Lunch Break | |
14:00 - 14:30 | Lena Berning Institute of Molecular Medicine I, Medical Faculty, Heinrich Heine University Düsseldorf | Identification of GRASP55 as a novel target of the natural compound prodigiosin |
14:30 - 15:00 | Flaminia Mazzone Institute of Medical Microbiology and Hospital Hygiene, Medical Faculty, Heinrich Heine University Düsseldorf | Expression, Characterization and Inhibition of Toxoplasma gondii DOXP Reductoisomerase |
| 15:00 - 15:45 | Bernd Riedl Bayer AG, Medicinal Chemistry | Chemical Post-Evolution of Natural Products in the field of Antibacterial Therapy |
15:45 | Closing Remarks | |