Publications

Our doctoral students contributed with their work to several publications and patents. Please find a lists of all publications of our GRK2158 fellows in 2020, 2019, 2018, 2017.

The special issue "Natural product-derived lead structures and modes-of-action against therapy-resistant tumors and microorganisms" in the Journal of Bioorganic & Medicinal Chemistry was edited by the Research Training Group 2158 speaker Holger Gohlke in 2019 and contains numerous contributions of scientists of the Research Training Group 2158.

2020
  • Friedrich, A., Assmann, A.-S., Schumacher, L., van Stuijvenberg, J., Kassack, M.U., Schulz, W.A., Roos, W.P., Hansen, F.K., Pflieger, M., Kurz, T., Fritz, G. (2020) In vitro assessment of the genotoxic hazard of novel hydroxamic acid- and benzamide-type histone deacetylase inhibitors (HDACi). Int J Mol Sci 21(13), 4747; doi.org/10.3390/ijms21134747
  • Weber, A., Breugst, M., Pietruszka, J. (2020) Experimental and Computational Investigations of the Reaction between α,β-unsaturated Lactones and 1,3-Dienes by Cooperative Lewis-Acid/Brønsted-Acid Catalysis. Angew. Chem. Int. Ed. DOI:10.1002/anie.202008365
  • Drießen, D., Biesen, L., Müller, T.J.J. (2020) Sequentially Catalyzed Three-Component Masuda–Suzuki–Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion. Synlett 31, DOI: 10.1055/s-0040-1707818.
  • Wu, W., Wang, X., Berleth, N., Deitersen, J., Wallot-Hieke, N., Böhler, P., Schlütermann, D., Stuhldreier, F., Cox, J., Schmitz, K., Seggewiß, S., Peter, C., Kasof, G., Stefanski, A., Stühler, K., Tschapek, A., Gödecke, A., Stork, B. (2020) The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death. Cell Reports 31: 107547
  • Ceccacci, S., Deitersen, J., Mozzicafreddo, M., Moretta, E., Proksch, P., Wesselborg, S., Stork, B., Monti, M.C. (2020) Carbamoyl-Phosphate Synthase 1 as a Novel Target of Phomoxanthone A, a Bioactive Fungal Metabolite.  Biomolecules 10(6): 846; doi.org/10.3390/biom10060846  
  • van Stuijvenberg, J., Proksch, P., Fritz, G. (2020) Targeting the DNA damage response (DDR) by natural compounds. Bioorg Med Chem. 28(4):115279. doi: 10.1016/j.bmc.2019.115279 (special issue, see below)
  • Mulnaes, D., Porta, N., Clemens, R., Apanasenko, I., Reiners, J., Gremer, L., Neudecker, P., Smits,. S.H.J., Gohlke, H. (2020) TopModel: Template-based protein structure prediction at loq sequence identity using top-down consensus and deep neural networks. JCTC dx.doi.org/10.1021/acs.jctc.9b00825
  • Asfaha, Y., Schrenk, C., Avelar, L.A.A., Lange, F., Wang, C., Bandolik, J.J., Hamacher, A., Kassack, M.U., Kurz, T. (2020) Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresitant cancer cells. Bioorg Med Chem 28(1):115108 (special issue, see below)
  • van Geelen, L., Kaschani, F., Sazzadeh, S.S., Adeniyi, E.T., Meier, D., Proksch, P., Pfeffer, K., Kaiser, M., Ioerger, T.R., Kalscheuer, R. (2020) Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria. Appl Microbiol Biotechnol 104: 5985–5998; doi: 10.1007/s00253-020-10654-4
  • Xie, B.,  Hänsel, J.,  Mundorf, V.,  Betz, J.,  Reimche, I.,  Erkan, M.,  Büdeyri, I.,  Gesell, A.,  Kerr, R. G.,  Ariantari, N. P.,  Yu, H.,  Proksch, P.,  Teusch, N., Mrsny, R. J. (2020) Pseudopterosin and O-Methyltylophorinidine Suppress Cell Growth in a 3D Spheroid Co-Culture Model of Pancreatic Ductal Adenocarcinoma. Bioengineering 7 (2): 57
  • Gao, Y., Stuhldreier, F., Schmitt, L., Wesselborg, S., Wang, L., Müller, W.E.G., Kalscheuer, R., Guo, Z., Zou, K., Liu, Z., Proksch, P. (2020) Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii. Fitoterapia, doi: 10.1016/j.fitote.2020.10465
  • Wang, C., Hamacher, A., Petzsch, P., Köhrer, K., Niegisch, G., Hoffmann, M.J., Schulz, W.A., Kassack, M.U. (2020) Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1. Cancers 12: 337 doi.org/10.3390/cancers12020337
  • Alachkar, A., Ojha, S.K., Sadeq, A., Adem, A., Frank, A., Stark, H., Sadek, B. (2020) Experimental models for discovery of novel anticonvulsant drugs: Focus on Pentylenetetrazole-induced seizures and associated memory deficits. Curr Pharm Des. 26(15): 1693-1711
  • Liu, Z., Frank, M., Yu, X., Yu, H., Tran-Cong, N.M., Gao, Y., Proksch, P. (2020) Secondary Metabolites from Marine-Derived Fungi from China. Progress in the Chemistry of Organic Natural Products 111. A. D. Kinghorn, H. Falk, S. Gibbons et al. Cham, Springer International Publishing: 81-153.
  • Ariantari, N.P., Ancheeva, E., Frank, M., Stuhldreier, F., Meier, D., Gröner, Y., Reimche, I. Teusch, N., Wesselborg, S., Müller, W.E.G., Kalscheuer, R., Liu, Z., Proksch, P. (2020) Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B.1, an endophyte of Terminalia catappa. RSC Adv. 10: 7232-7240
  • Tran‐Cong, N.M., Mándi, A., Király, S.B., Kurtán, T.,Lin, W., Liu Z., Proksch, P. (2020)  Furoic acid derivatives from the endophytic fungus Coniothyrium sp. Chirality 1-6 DOI: 10.1002/chir.23209
  • Greb, J., Pietruszka, J. (2020) Jahresrückblick Organische Chemie: Naturstoff(total)synthese. Nachr. Chem. Tech. Lab. 68: 10-11
2019
  • Harwoko, H., Daletos, G., Stuhldreier, F., Lee, J., Wesselborg, S., Feldbrügge, M., Müller, W.E.G., Kalscheuer, R., Ancheeva, E., Proksch, P. (2019) Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigru. Nat. Prod. Res.DOI: 10.1080/14786419.2019.1627348
  • Mayer, S., Prechtl, M., Liebfried, P., Cadeddu, R-P., Stuhldreier, F., Kohl, M., Wenzel, F., Stork, B., Wesselborg, S., Proksch, P., Germing, U., Haas, R., Jäger, P. (2019) First Results from a Screening of 300 Naturally Occurring Compounds: 4,6-dibromo-2-(2′,4′-dibromophenoxy)phenol, 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol, and 5-epi-nakijinone Q as Substances with the Potential for Anticancer Therapy. Mar. Drugs 17(9), 521 https://doi.org/10.3390/md17090521
  • Sachs, J., Kadioglu, O., Weber, A., Mundorf, V., Betz, J., Efferth, T., Pietruszka, J., Teusch, N. (2019) Selective inhibition of P-gp transporter by goniothalamin derivatives sensitizes resistant cancer cells to chemotherapy. J Nat Med 73, 226-235
  • Stank, L., Frank, A., Hagenow, S., Stark, H. (2019) Talipexole variations as novel bitopic dopamine D2 and D3 receptor ligands, Med Chem Comm 10: 1926-1929 DOI: 10.1039/C9MD00379G.
  • Frank, A., Meza, F., Salas, C. O., Fierro, A., Espinosa-Bustos, C., and Stark, H. (2019) From Natural Compounds to Small Molecules Targeting the Histamine H3 Receptor. Inflamm Res 58, S42
  • Yu, H., Höfert, S-P., Moussa, M., Janiak, C., Müller, W.E.G., Umeokoli, B.O., Dai, H., Liu, Z., Proksch, P. (2019) Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a. Tetrahydron Lett 60(15). 1513125
  • Carbone, C., Russo, S.L.M.L., Lacivita, E., Frank, A., Alleva, E., Stark, H., Saso, L., Leopoldo, M., Adriani, W. (2019) Prior activation of 5-HT7 receptors modulates the conditioned place preference with methylphenidate. Front Behav Neurosci doi.org/10.3389/fnbeh.2019.00208
  • Ariantari, N.P., Ancheeva, E., Wang, C., Mándi, A., Knedel, T.O, Kurtán, T., Chaidir, C., Müller, W.E.G., Kassack, M.U., Janiak, C., Daletos, G., Proksch, P. (2019) Indole diterpenoids from the fungal endophyte Penicillium sp. J Nat Prod 82(6): 1412-23
  • Schmidt, D., Boehm, M., McClendon, C.L., Torella, R., Gohlke, H. (2019) Cosolvent-enhanced sampling and unbiased identification of cryptic pockets suitable for structure-based drug design. J. Chem. Theory Comput. 15, 3331-3343.
  • Moussa, M., Ebrahim, W., Bonus, M., Gohlke, H., Mándi, A., Kurtán, T., Hartmann, R., Kalscheuer, R., Lin, W., Liu, Z., Proksch, P. (2019) Co-culture of the fungus Fusarium tricinctum with Streptomyces lividans induces production of cryptic naphtoquinone dimers. RSC Adv. 9, 1491–1500.
  • Tran-Cong, N.M., Mandi, A., Kurtán, T., Müller, W.E.G., Kalscheuer, R., Lin, W., Liu, Z., Proksch, P. (2019) Induction of cryptic metabolites of the endophytic fungus Trichocladium sp. through OSMAC and co-cultivation. RSC Adv. 9: 27279
  • Bandolik, J.J., Hamacher, A., Schrenk, C., Weishaupt, R., Kassack, M.U. (2019) Class I-histone deacetylase (HDAC) inhibition is superior to pan-HDAC inhibition in modulating cisplatin potency in high grade serous ovarian cancer cell lines. Int J Mol Sci DOI: 10.3390/ijms20123052
  • Yu, H., Sperlich, J., Hofert, S.-P., Janiak, C., Teusch, N., Stuhldreier, F., Wesselborg, S., Wang, C., Kassack, M.U., Dai, H., Liu, Z., Proksch, P. (2019). Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariaeFitoterapia 137: 104249.
  • Richter, L., Kropp, S., Proksch, P., Scheu, S. (2019) A mouse model-based screening platform for the identification of immune activating compounds such as natural products for novel cancer immunotherapies. Bioorg Med Chem DOI: 10.1016/j.bmc.2019.115145 (special issue, see below)
  • Scheu, S., Ali, S., Mann-Nüttel, R., Richter, L., Arolt, V., Dannlowski, U., Kuhlmann, T., Klotz, L., Alferink, J., (2019) Interferon β-mediated protective functions of microglia in central nervous system autoimmunity. IJMS 20: 190
  • Ali, S., Mann-Nüttel, R., Schulze, A., Richter, L., Alferink, J., Scheu, S. (2019) Sources of type I interferons in infectious immunity: Plasmacytoid dendritic cells not always in the driver's seat. Front Immunol DOI: 10.3389/fimmu.2019.00778
  • Asfaha, Y., Schrenk, C., Avelar, L.A.A., Hamacher, A., Pflieger, M., Kassack, M.U., Kurz, T. (2019) Recent advances in class IIa histone deacetylases research. Bioorg Med Chem DOI: 10.1016/j.bmc.2019.115087 (special issue, see below)
  • Abdel-Wahab, N.M., Harwoko, H., Müller, W.E.G., Hamacher, A., Kassack, M.U., Fouad, M.A., Kamel, M.S., Lin, W., Ebrahim, W., Liu, Z., Proksch, P. (2019) Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea. Bioorg Med Chem 27: 3954-3959 (special issue, see below)
  • Form, I.C., Bonus, M., Gohlke, H., Lin, W., Daletos, G., Proksch, P. (2019) Xanthone, benzophenone and bianthrone derivatives from the hypersaline lake-derived fungus Aspergillus wentii. Bioorg Med Chem 27(20):115005 (special issue, see below)
  • Porta, N., Zaschke-Kriesche, J., Frieg, B., Gopalswamy, M., Zivkovic, A., Etzkorn, M., Stark, H., Smits, S.H.J., Gohlke, H. (2019) Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae. Bioorg Med Chem 27(20):115079 (special issue, see below)
  • Deitersen, J., El-Kashef, D.H., Proksch, P., Stork, B. (2019) Anthraquinones and autophagy – Three rings to rule them all? Bioorg Med Chem 27(20):115042 (special issue, see below)
  • Pflieger, M., Hamacher, A., Öz, T., Horstick-Muche, N., Boesen, B., Schrenk, C., Kassack, M.U., Kurz, T. (2019) Novel α,β-unsaturated hydroxamic acid derivatives overcome cisplatin resistance. Bioorg Med Chem 27:115036 (special issue, see below)
  • Bickel, D., Gohlke, H. (2019) C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action. Bioorg Med Chem 27(21):115080 (special issue, see below)
  • Wang, C., Engelke, L., Bickel, D., Hamacher, A., Frank, M., Proksch, P., Gohlke, H., Kassack, M.U. (2019) The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. Bioorg Med Chem 27(19):115044 (special issue, see below)
  • Frank, A., Meza-Arriagada, F., Salas, C.O., Espinosa-Bustos, C., Stark, H. (2019) Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H3 receptor. Bioorg Med Chem 27:3194-3200 (special issue, see below)
  • Drießen, D., Stuhldreier, F., Frank, A., Stark, H., Wesselborg, S., Stork, B., Müller, T.J.J. (2019) Novel meriolin derivatives as rapid apoptosis inducers. Bioorg Med Chem 27: 3463-3468 (special issue, see below)
  • Zaschke-Kriesche, J., Reiners, J., Lagedroste, M., Smits, S.H. (2019) Influence of nisin hinge-region variants on lantibiotic immunity and resistance proteins, Bioorg Med Chem 27:3947-3953 (special issue, see below)
  • Mechsner, B., Böse, D., Hogenkamp, F., Ledermann, N., Hartmann, R., Bochinsky, K., Frey, W., Pietruszka, J. (2019) Enantioselective total synthesis of altersolanol A and N. Bioorg Med Chem 27: 2991-2997 (special issue, see below)
  • Zaschke-Kriesche, J., Behrmann, L.V., Reiners, J., Lagedroste, M., Gröner, Y., Kalscheuer, R., Smits, S.H. (2019) Bypassing lantibiotic resistance by an effective nisin derivative, Bioorg Med Chem 27:3454-3462 (special issue, see below)
  • Sachs, J., Döhl, K., Weber, A.,  Bonus, M., Ehlers, F., Fleischer, E., Klinger, A., Gohlke, H., Pietruszka, J., Schmitt, L., Teusch, N. (2019) Novel 3,4-dihydroisocoumarines inhibit human P-gp and BCRP in multidrug resistant tumors and demonstrate substrate inhibition of yeast Pdr5, Front. Pharmacol. 10:400
2018
  • Rehberg, N., Akone, H.S., Loerger, T.R., Erlenkamp, G., Daletos, G., Gohlke, H., Proksch, P., Kalscheuer, R. (2018) Chlorflavonin targets acetohydroxyacid synthase catalytic subunit IlvB1 for synergistic killing of Mycobacterium tuberculosis. ACS Infect. Dis. 4, 123-134.
  • Yu, H., Sperlich, J., Mándi, A., Kurtán, T., Dai, H., Teusch, N., Guo, Z.-Y., Zou, K., Liu, Z., Proksch, P. (2018) Azaphilone derivatives from the fungus Coniella fragariae inhibit NF-κB activation and reduce tumor cell migration. J Nat Prod 81(11):2493-2500
  • Frank, A., Kiss, D.J., Keserü, G.M., Stark, H. (2018) Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor. SciRep 8:12509
  • Espinosa-Bustos, C., Frank, A., Arancibia-Opazo, S., Salas, C. O., Fierro, A., Stark, H. (2018) New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class. Bioorg & Med Chem Lett 28:2890-2893
  • Böhler, P., Stuhldreier, F., Anand, R., Kondadi A.K., Schlütermann, D., Berleth, N., Deitersen, J., Wallot-Hieke, N., Wu, W., Frank, M., Niemann, H., Wesbuer, E., Barbian, A., Luyten, T., Parys, j.B., Weidtkamp-Peters, S., Borchardt, A., Reichert, A., Pena-Blanco, A., Garcia-Saez, A.J., Itskanov, S., van der Bliek, A.M., Proksch, P., Wesselborg, S., Stork, B. (2018) The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death and Disease 9:286 
  • Schlütermann, D., Skowron, M.A., Berleth, N., Böhler, P., Deitersen, J., Stuhldreier, F., Wallot-Hieke, N., Wu, W., Peter, C., Hoffmann, M.J., Niegisch, G., Stork, B. (2018) Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex. Urol Oncol. 36(4):160
  • Wallot-Hieke, N., Verma, N., Schlütermann, D., Berleth, N., Deitersen, J., Böhler, P., Stuhldreier, F., Wu, W., Seggewiß, S., Peter, C., Gohlke, H., Mizushima, N., Stork, B. (2018) Systematic analysis of ATG13 domain requirements for autophagy induction. Autophagy 14:743-761
  • Clemens, R., Zaschke-Kriesche, J., Khosa S., Smits S.H.J. (2018) Insight into two ABC transporter families involved in lantibiotic resistance. Front. Mol. Biosci. 4:91 
  • Krüger, K., Geist, K., Stuhldreier, F., Schumacher, L., Blümel, L., Remke, M., Wesselborg, S., Stork, B., Klöcker, N., Bormann, S., Roos, W.P., Honnen, S., Fritz, G. (2018) Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells. Cancer Lett 430:34-46
  • Brückmann, H., Frank, A., Reiner, D., Stark, H. (2018) Pharmakotherapie des Restless-Legs-Syndroms – eine detaillierte Betrachtung. Pharmakon 1/2018
  • Alachkar, A., Lazewska, D., Latacz, G., Frank, A., Siwek, A., Lubelska, A., Honkisz-Orzechowska, E., Handzlik, J., Stark, H., Kiec-Kononowicz, K., Sadek, B. (2018) Studies on Anticonvulsant Effects of Novel Histamine H3R Antagonists in Electrically and Chemically Induced Seizures in Rats. Int J Mol Sci 19:3386
  • Kaletsch, A., Pinkemeil, M., Hoffmann, M.J., Jaguva Vasudevan, A.A., Wang, C., Hansen, F.K., Wiek, C., Hanenberg, H., Gertzen, C., Gohlke, H., Kassack, M.U., Kurz, T., Schulz, W.A., Niegisch, G. (2018) Effects of novel HDAC inhibitors on urothelial carcinoma cells. Clinical Epigenetics 10:100
  • Schipp, C., Schlütermann, D., Hönscheid, A., Nabhani, S., Höll, J., Oommen, P.T., Ginzel, S., Fleckenstein, B., Stork, b., Borkhardt, A., Stepensky, P., Fischer, U. (2018) EBV negative lymphoma and autimmune lymphoproliferative syndorem like phenotype extend the clinical spectrum of primary immunodeficiency caused by STK4 deficiency. Front Immunol 9:2400
2017
  • Reiners, J., Lagedroste, M., Ehlen, K., Leusch, S., Zaschke-Kriesche, J., Smits, S. H. J. (2017) The N-terminal region of nisin is important for the BceAB-Type ABC transporter NsrFP from Streptococcus agalactiae COH1. Frontiers in Microbiology 8: 1643   
  • Frank, A., Abu-Lafi, S., Adawi, A., Schwed, J.S., Stark, H., Rayan, A. (2017) From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation. Inflamm Res. 66(10):923-929 
  • Weber, A., Döhl, K., Sachs, J., Nordschild, A.C.M., Schröder, D., Kulik, A., Fischer, T., Schmitt, L., Teusch, N., Pietruszka, J. (2017) Synthesis and cytotoxic activities of goniothalamins and derivatives. Bioorg. Med. Chem., 25: 6115-6125
  • Sperlich, J., Kerr, R., Teusch, N. (2017). The marine natural product pseudopterosin blocks cytokin release of triple-negative breast cancer and monocytic leukemia cells by inhibiting NF-κB signaling. Marine Drugs 15: 262 
  • Mokhlesi, A., Stuhldreier, F., Wex, K.W., Berscheid, A., Hartmann, R., Rehberg, N., Sureechatchaiyan, P., Chaidir, C., Kassack, M.U., Kalscheuer, R., Brötz-Oesterhelt, H., Wesselborg, S., Stork, B., Daletos, G., Proksch, P. (2017) Cyclic cystine-bridged peptides from the marine sponge Clathria basilana induce apoptosis in tumor cells and depolarize the bacterial cytoplasmic membrane. J Nat Prod 80(11):2941-2952
  • Lang, A., Anand, R., Altinoluk-Hambüchen, S., Ezzahoini, H., Stefanski, A., Iram, A., Bergmann, L., Urbach, J., Böhler, P., Hänsel, J., Franke, M., Stühler, K., Krutmann, J., Scheller, J., Stork, B., Reichert, A.S., Piekorz, R.P. (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9(10):2163-2189
  • Liu, Y., Stuhldreier, F., Kurt, T., Mandi, A., Arumugam, S., Lin, W., Stork, B., Wesselborg, S., Weber, H., Henrich, B., Daletos, G., Proksch, P. (2017) Daldinone derivatives from the mangrove-derived endophytic fungus Annulohypoxylon sp. RSC Advances 7, 5381-5393
Patents
  • T. J. J. Müller, G. Sommer, B. O. A. Tasch, R. Kalscheuer, N. Rehberg (2018) Bis-Indole Derivatives for Use in the Treatment of Bacterial Infections, WO2018060367 (A1) - 2018-04-05; EP3301096 (A1) - 2018-04-04.
Special Issue "Natural product-derived lead structures and modes-of-action against therapy-resistant tumors and microorganisms" in Journal of Bioorganic & Medicinal Chemistry

Several scientists of Research Training Group 2158 contributed to this special issue, which is edited by by the Research Training Group 2158 speaker Holger Gohlke, and thus demonstrate the close cooperation of the groups working in the Research Training Group and their work on the field of natural product research (Publications of our doctoral students are listed above).

More information about this issue: https://www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry/special-issue/10WBM0BS0L1

Responsible for the content: E-MailMartina Holz