Publications

Our doctoral students contributed with their work to several publications. Please find a lists of all publications of our GRK2158 fellows in undefined2019, undefined2018, undefined2017.

The undefinedspecial issue "Natural product-derived lead structures and modes-of-action against therapy-resistant tumors and microorganisms" in the Journal of Bioorganic & Medicinal Chemistry was edited by the Research Training Group 2158 speaker Holger Gohlke in 2019 and contains numerous contributions of scientists of the Research Training Group 2158. 

    2019
    • Tran-Cong, N.M., Mandi, A., Kurtán, T., Müller, W.E.G., Kalscheuer, R., Lin, W., Liu, Z., Proksch, P. (2019) Induction of cryptic metabolites of the endophytic fungus Trichocladium sp. through OSMAC and co-cultivation. RSC Adv. 9: 27279
    • Bandolik, J.J., Hamacher, A., Schrenk, C., Weishaupt, R., Kassack, M.U. (2019) Class I-histone deacetylase (HDAC) inhibition is superior to pan-HDAC inhibition in modulating cisplatin potency in high grade serous ovarian cancer cell lines. Int J Mol Sci DOI: 10.3390/ijms20123052
    • Yu, H., J. Sperlich, S. P. Hofert, C. Janiak, N. Teusch, F. Stuhldreier, S. Wesselborg, C. Wang, M. U. Kassack, H. Dai, Z. Liu and P. Proksch (2019). Azaphilone pigments and macrodiolides from the coprophilous fungus Coniella fragariaeFitoterapia 137: 104249.
    • Asfaha, Y., Schrenk, C., Avelar, L.A.A., Lange, F., Wang, C., Bandolik, J.J., Hamacher, A., Kassack, M.U., Kurz, T. (2019) Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresitant cancer cells. Bioorg Med Chem DOI: 10.1016/j.bmc.2019.115108 (special issue, see below)
    • Richter, L., Kropp, S., Proksch, P., Scheu, S. (2019) A mouse model-based screening platform for the identification of immune activating compounds such as natural products for novel cancer immunotherapies. Bioorg Med Chem DOI: 10.1016/j.bmc.2019.115145 (special issue, see below)
    • Scheu, S., Ali, S., Mann-Nüttel, R., Richter, L., Arolt, V., Dannlowski, U., Kuhlmann, T., Klotz, L., Alferink, J., (2019) Interferon β-mediated protective functions of microglia in central nervous system autoimmunity. IJMS 20: 190
    • Ali, S., Mann-Nüttel, R., Schulze, A., Richter, L., Alferink, J., Scheu, S. (2019) Sources of type I interferons in infectious immunity: Plasmacytoid dendritic cells not always in the driver's seat. Front Immunol DOI: 10.3389/fimmu.2019.00778
    • Asfaha, Y., Schrenk, C., Avelar, L.A.A., Hamacher, A., Pflieger, M., Kassack, M.U., Kurz, T. (2019) Recent advances in class IIa histone deacetylases research. Bioorg Med Chem DOI: 10.1016/j.bmc.2019.115087 (special issue, see below)
    • Abdel-Wahab, N.M., Harwoko, H., Müller, W.E.G., Hamacher, A., Kassack, M.U., Fouad, M.A., Kamel, M.S., Lin, W., Ebrahim, W., Liu, Z., Proksch, P. (2019) Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea. Bioorg Med Chem 27: 3954-3959 (special issue, see below)
    • Form, I.C., Bonus, M., Gohlke, H., Lin, W., Daletos, G., Proksch, P. (2019) Xanthone, benzophenone and bianthrone derivatives from the hypersaline lake-derived fungus Aspergillus wentii. Bioorg Med Chem 27(20):115005 (special issue, see below)
    • Porta, N., Zaschke-Kriesche, J., Frieg, B., Gopalswamy, M., Zivkovic, A., Etzkorn, M., Stark, H., Smits, S.H.J., Gohlke, H. (2019) Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae. Bioorg Med Chem 27(20):115079 (special issue, see below)
    • Deitersen, J., El-Kashef, D.H., Proksch, P., Stork, B. (2019) Anthraquinones and autophagy – Three rings to rule them all? Bioorg Med Chem 27(20):115042 (special issue, see below)
    • Pflieger, M., Hamacher, A., Öz, T., Horstick-Muche, N., Boesen, B., Schrenk, C., Kassack, M.U., Kurz, T. (2019) Novel α,β-unsaturated hydroxamic acid derivatives overcome cisplatin resistance. Bioorg Med Chem 27:115036 (special issue, see below)
    • Bickel, D., Gohlke, H. (2019) C-terminal modulators of heat shock protein of 90 kDa (HSP90): State of development and modes of action. Bioorg Med Chem 27(21):115080 (special issue, see below)
    • Wang, C., Engelke, L., Bickel, D., Hamacher, A., Frank, M., Proksch, P., Gohlke, H., Kassack, M.U. (2019) The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells. Bioorg Med Chem 27(19):115044 (special issue, see below)
    • Frank, A., Meza-Arriagada, F., Salas, C.O., Espinosa-Bustos, C., Stark, H. (2019) Nature-inspired pyrrolo[2,3-d]pyrimidines targeting the histamine H3 receptor. Bioorg Med Chem 27:3194-3200 (special issue, see below)
    • Drießen, D., Stuhldreier, F., Frank, A., Stark, H., Wesselborg, S., Stork, B., Müller, T.J.J. (2019) Novel meriolin derivatives as rapid apoptosis inducers. Bioorg Med Chem 27: 3463-3468 (special issue, see below)
    • Zaschke-Kriesche, J., Reiners, J., Lagedroste, M., Smits, S.H. (2019) Influence of nisin hinge-region variants on lantibiotic immunity and resistance proteins, Bioorg Med Chem 27:3947-3953
      (special issue, see below)
    • Mechsner, B., Böse, D., Hogenkamp, F., Ledermann, N., Hartmann, R., Bochinsky, K., Frey, W., Pietruszka, J. (2019) Enantioselective total synthesis of altersolanol A and N. Bioorg Med Chem 27: 2991-2997 (special issue, see below)
    • Zaschke-Kriesche, J., Behrmann, L.V., Reiners, J., Lagedroste, M., Gröner, Y., Kalscheuer, R., Smits, S.H. (2019) Bypassing lantibiotic resistance by an effective nisin derivative, Bioorg Med Chem 27:3454-3462 (special issue, see below)
    • Sachs, J., Döhl, K., Weber, A.,  Bonus, M., Ehlers, F., Fleischer, E., Klinger, A., Gohlke, H., Pietruszka, J., Schmitt, L., Teusch, N. (2019) Novel 3,4-dihydroisocoumarines inhibit human P-gp and BCRP in multidrug resistant tumors and demonstrate substrate inhibition of yeast Pdr5, Front. Pharmacol. 10:400
      2018
      • Yu, H., Sperlich, J., Mándi, A., Kurtán, T., Dai, H., Teusch, N., Guo, Z.-Y., Zou, K., Liu, Z., Proksch, P. (2018) Azaphilone derivatives from the fungus Coniella fragariae inhibit NF-κB activation and reduce tumor cell migration. J Nat Prod 81(11):2493-2500
      • Frank, A., Kiss, D.J., Keserü, G.M., Stark, H. (2018) Binding kinetics of cariprazine and aripiprazole at the dopamine D3 receptor. SciRep 8:12509
      • Espinosa-Bustos, C., Frank, A., Arancibia-Opazo, S., Salas, C. O., Fierro, A., Stark, H. (2018) New lead elements for histamine H3 receptor ligands in the pyrrolo[2,3-d]pyrimidine class. Bioorg & Med Chem Lett 28:2890-2893
      • Böhler, P., Stuhldreier, F., Anand, R., Kondadi A.K., Schlütermann, D., Berleth, N., Deitersen, J., Wallot-Hieke, N., Wu, W., Frank, M., Niemann, H., Wesbuer, E., Barbian, A., Luyten, T., Parys, j.B., Weidtkamp-Peters, S., Borchardt, A., Reichert, A., Pena-Blanco, A., Garcia-Saez, A.J., Itskanov, S., van der Bliek, A.M., Proksch, P., Wesselborg, S., Stork, B. (2018) The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death and Disease 9:286 
      • Schlütermann, D., Skowron, M.A., Berleth, N., Böhler, P., Deitersen, J., Stuhldreier, F., Wallot-Hieke, N., Wu, W., Peter, C., Hoffmann, M.J., Niegisch, G., Stork, B. (2018) Targeting urothelial carcinoma cells by combining cisplatin with a specific inhibitor of the autophagy-inducing class III PtdIns3K complex. Urol Oncol. 36(4):160
      • Wallot-Hieke, N., Verma, N., Schlütermann, D., Berleth, N., Deitersen, J., Böhler, P., Stuhldreier, F., Wu, W., Seggewiß, S., Peter, C., Gohlke, H., Mizushima, N., Stork, B. (2018) Systematic analysis of ATG13 domain requirements for autophagy induction. Autophagy 21:1-21
      • Clemens, R., Zaschke-Kriesche, J., Khosa S., Smits S.H.J. (2018) Two ABC transporter families involved in lantibiotic resistance. Front. Mol. Biosci. 4:91 
      • Kürger, K., Geist, K., Stuhldreier, F., Schumacher, L., Blümel, L., Remke, M., Wesselborg, S., Stork, B., Klöcker, N., Bormann, S., Roos, W.P., Honnen, S., Fritz, G. (2018) Multiple DNA damage-dependent and DNA damage-independent stress responses define the outcome of ATR/Chk1 targeting in medulloblastoma cells. Cancer Lett 430:34-46
      • Brückmann, H., Frank, A., Reiner, D., Stark, H. (2018) Pharmakotherapie des Restless-Legs-Syndroms – eine detaillierte Betrachtung. Pharmakon 1/2018
        2017
        • Reiners, J., Lagedroste, M., Ehlen, K., Leusch, S., Zaschke-Kriesche, J., Smits, S. H. J. (2017) The N-terminal region of nisin is important for the BceAB-Type ABC transporter NsrFP from Streptococcus agalactiae COH1. Frontiers in Microbiology 8: 1643   
        • Frank, A., Abu-Lafi, S., Adawi, A., Schwed, J.S., Stark, H., Rayan, A. (2017) From medicinal plant extracts to defined chemical compounds targeting the histamine H4 receptor: Curcuma longa in the treatment of inflammation. Inflamm Res. 66(10):923-929 
        • Weber, A., Döhl, K., Sachs, J., Nordschild, A.C.M., Schröder, D., Kulik, A., Fischer, T., Schmitt, L., Teusch, N., Pietruszka, J. (2017) Synthesis and cytotoxic activities of goniothalamins and derivatives. Bioorg. Med. Chem., 25: 6115-6125
        • Sperlich, J., Kerr, R., Teusch, N. (2017). The marine natural product pseudopterosin blocks cytokin release of triple-negative breast cancer and monocytic leukemia cells by inhibiting NF-κB signaling. Marine Drugs 15: 262 
        • Mokhlesi, A., Stuhldreier, F., Wex, K.W., Berscheid, A., Hartmann, R., Rehberg, N., Sureechatchaiyan, P., Chaidir, C., Kassack, M.U., Kalscheuer, R., Brötz-Oesterhelt, H., Wesselborg, S., Stork, B., Daletos, G., Proksch, P. (2017) Cyclic cystine-bridged peptides from the marine sponge Clathria basilana induce apoptosis in tumor cells and depolarize the bacterial cytoplasmic membrane. J Nat Prod 80(11):2941-2952
        • Lang, A., Anand, R., Altinoluk-Hambüchen, S., Ezzahoini, H., Stefanski, A., Iram, A., Bergmann, L., Urbach, J., Böhler, P., Hänsel, J., Franke, M., Stühler, K., Krutmann, J., Scheller, J., Stork, B., Reichert, A.S., Piekorz, R.P. (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9(10):2163-2189
          Special Issue "Natural product-derived lead structures and modes-of-action against therapy-resistant tumors and microorganisms" in Journal of Bioorganic & Medicinal Chemistry

          Several scientists of Research Training Group 2158 contributed to this special issue, which is edited by by the Research Training Group 2158 speaker Holger Gohlke, and thus demonstrate the close cooperation of the groups working in the Research Training Group and their work on the field of natural product research (Publications of our doctoral students are listed above).

          More information about this issue: https://www.sciencedirect.com/journal/bioorganic-and-medicinal-chemistry/special-issue/10WBM0BS0L1

          Responsible for the content: E-MailMartina Holz