Symposium 2018

It is a pleasure to announce that the second symposium of Research Training Group 2158 (GRK2158) will take place from September 17th till 21st 2018 in Beijing, China.

The long-standing cooperation between the Institute of Pharmaceutical Biology of the University of Duesseldorf and undefinedPeking University is not only a basis for a fruitful exchange of knowledge about natural products, but has now led to the joint organization of this year's symposium in Beijing, China.

50 participants from Heinrich Heine University and Chinese Universities and Research institutes will meet at the Conference Center of Medical Health Center of Peking University and discuss their research on Natural compounds and analogs against therapy resistant tumours and microorganisms.

More information about the programm etc. you can find undefinedhere

Haiqian Yu wins Poster Prize!

Haiqian Yu, 3rd PSE Meeting on Natural Compounds in Cancer Prevention and Therapy, Naples, Italy

Our doctoral student Haiqian Yu has been awarded the Elsevier Best Poster Prize at the 3rd International PSE Congress on Natural Compounds in Cancer Prevention and Therapy. Haiqian is working in the undefinedInstitute of Pharmaceutical Biology under supervision of Prof. Dr. Peter Proksch. At the PSE Congress Haiqian presented a poster of his work concerning "Azaphilone derivatives from the fungus Coniella fragariae inhibit NF-κB activation and reduce tumor cell migration".

Congratulation to Haiqian!

The congress of the Phytochemical Society of Europe [PSE] took place in Naples, Italy, from Sept 4 to 7 2018. More information on this conference you cann find undefinedhere

Congratulations Gereon!

At the beginning of May 2018 Gereon Sommer defended his doctoral thesis successfully. Gereon worked in the group of Thomas J.J. Müller on the Masuda-Borylation-Suzuki-Coupling as an efficient work tool for the synthesis of active agents.


Congratulations Anja!

Anja Weber née Ullrich, who worked in undefinedJörg Pietruszka's research group, defended her doctoral thesis in the field of natural compound/active agent synthesis successfullyon April the 10th 2018.


Identification of phomoxanthone A as a mitochondrial toxin

New insights in the mode of action of phomoxanthone A (PXA) were given in the new publication of Böhler et al. 2018. In close collaboration with several groups from Heinrich Heine University, KU Leuven, University of Tübingen and UCLA the mycotoxin PXA, derived from the endophytic fungus Phomopsis longicolla, was identified as an mitochondrial toxin by causing disruption of mitochondrial function, IMM fragmentation and cristae disruption leading to the release of pro-apoptotic factors and thus to apoptosis.

The article was published in Cell Death & Disease:

Böhler, P., Stuhldreier, F., Anand, R., Kondadi A.K., Schlütermann, D., Berleth, N., Deitersen, J., Wallot-Hieke, N., Wu, W., Frank, M., Niemann, H., Wesbuer, E., Barbian, A., Luyten, T., Parys, j.B., Weidtkamp-Peters, S., Borchardt, A., Reichert, A., Pena-Blanco, A., Garcia-Saez, A.J., Itskanov, S., van der Bliek, A.M., Proksch, P., Wesselborg, S., Stork, B. (2018) The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane. Cell Death and Disease 9:286

Link to publication

Nicola Porta wins Poster Award at 32. Molecular Modelling Workshop 2018

We are happy to announce that our PhD fellow Nicola Porta, who is working in Holger Gohlke's group at the undefinedInstitute of Pharmaceutical and Medicinal Chemistry, received a Poster Award for his work on the "Impact of allosteric inhibitors on MRSA pyruvate kinase conformational dynamics" at the 32nd Molecular Modelling Workshop 2018 in Erlangen.


More information about the Molecular Modelling Workshop 2018 you can find here:

GRK2158 Symposium

The first internal Symposium of Research Training Group 2158 was held from 20th till 22nd of September in "Schloß Mickeln" in Düsseldorf. This event was a perfect occasion for all doctoral students and principal investigators to come together, get connected, discuss and forward their projects.

All doctoral students presented their projects via oral presentations and posters.

Special highlights were the talks of the invited speakers Prof. Dr. Wenhan Lin from Peking University, China, Dr. Min Li-Weber from German Cancer Research Center (DKFZ) in Heidelberg and Prof. Dr. Mark Brönstrup from Helmholtz Centre for Infection Research in Braunschweig.

Responsible for the content: E-MailMartina Holz